In recent years, an anti-aging substance has quickly become popular in the academic world and is even considered to be the most anticipated effective anti-aging substance of this century. If you want to extend your healthy life span, then it is the secret weapon you need, it is akg!
Compared with the top anti-aging substances that have been popularized before, such as PQQ, NAD+spermidine, what is unique about akg? Why is it more popular than nmn abroad? So today I will show you the anti-aging secrets of akg.
Akg is also called α-ketoglutaric acid, which is actually a precursor of ATP and can be naturally produced in the human body. The benefits of Akg to us mainly come from its mechanism of action. It can stimulate the body to produce more energy, synthesize essential proteins for the human body, improve the function of mitochondria, and enhance the repair ability of cells. Hearing this, we feel that the function of Akg is very similar to that of PQQ. But why did this substance suddenly become popular in Europe and the United States? Even David Sinclair, the discoverer of the anti-aging godfather NMN, abandoned NMN and plunged into the anti-aging field of Akg!
In 2014, the top journal Nature published the first research on the anti-aging field of akg, which proved for the first time that akg can extend the lifespan of Caenorhabditis elegans by 50%, and has excellent potential in activating the AMPK signaling pathway, reducing the level of inflammatory factors, anti-oxidation and activating the expression of longevity genes. This is the first time that akg has emerged in the anti-aging field. What made akg famous was the Brianclity team of the National University of Singapore. In 2021, they published a very heavy paper, proving that after taking α-ketoglutarate for seven months, the human body's epigenetic physiological age was reversed by about eight years. In terms of epigenetic optimization, akg is of great help, which has greatly improved and reversed the various physical functions and indicators of these subjects. They found out through genetic testing that akg reduced the age by 7 to 8 years in epigenetics, confirming that akg can successfully reverse the age of subjects by 7 to 8 years.
Maybe you don't know how valuable this thing is, because NMN, which can rejuvenate mice and has the most anti-aging potential, has not been able to prove its effectiveness on humans in human trials. The human experiment of MMN is still in the clinical phase II. After seven years of human clinical research, Akg has confirmed for the first time that this substance can reverse the physiological age of humans by eight years. Moreover, these research results are based on clinically relevant health markers, HSPN markers. It is the first time in research involving mammals, and this is a human study, not an animal study on monkeys or mice. Therefore, it has suddenly become popular in Europe and the United States for a good reason. In fact, the working principle of Akg is very similar to that of PQQ and MMM. The similarity is that as the human body ages, our metabolic capacity gradually decreases, and the human body produces less and less Akg, PQQ and NMN, which leads to a decline in the human immune function. Our DNA is more prone to lesions and expression errors, which will lead to accelerated aging. Therefore, it is necessary to increase cell activity through exogenous supplementation, prolong the life of DNA, and make it express more accurately!
However, there are some differences in their anti-aging points. The NAD coenzyme mainly works on extending the length of chromosome telomeres, making gene expression more stable and causing fewer errors. PQQ mainly works on the supply of energy for cell mitochondria, that is, keeping the body in a more energy-sufficient and stable state.
Akg, alpha-ketoglutarate, is an intermediate metabolite of the human body's tricosyl acid cycle. In addition to being of great help to mitochondria and making your tricosyl acid cycle stronger, the current mechanism of action of Akg is actually very complex. Current research has found that this ingredient has many determinants for anti-aging effects on the human body. One of the very useful effects is to activate Tet protein. Tet protein is a regulatory protein for DNA demethylation. This gene transferase can remove excessive methylation at the DNA level. If your methylation is excessive, it will get better very quickly. We need a positive methylation cycle, which means demethylation is needed to help you reverse aging.
In addition, alpha-ketoglutaric acid can also activate the body's AMPK. At the same time, many experiments have proved that AKB is a powerful substance that can activate the endogenous antioxidant pathway in the human body. It is called the most promising anti-aging substance in contemporary times. It is indeed well-deserved. However, the difference between this ingredient and others is that it cannot be obtained through food. It is not like PQQ, NAD and other substances, which are contained in natural foods. Therefore, once AKB starts to decay in your body, you actually have no other way to supplement it. Therefore, at present, it seems that the only way to increase the AKB content is through artificial supplements.
